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| Latest Insider Trading | Top Insider Trading Recent Week | Top 10% Owner Trading Recent Week | Filter
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| Ticker | Owner | Relationship | Date | Transaction | Cost  |
#Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| PEPG | KEATING LAURIE | Director | May 06 | Buy | 12.00 | 4,166 | 49,992 | 4,166 | Jan 19 05:17 PM |
| IMRX | KEATING LAURIE | Director | May 16 | Buy | 5.00 | 7,000 | 35,000 | 14,000 | May 17 05:15 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Aug 05 | Option Exercise | 88.95 | 10,000 | 889,500 | 15,132 | Aug 09 04:09 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Aug 05 | Sale | 188.95 | 10,000 | 1,889,500 | 5,132 | Aug 09 04:09 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Jul 12 | Option Exercise | 87.90 | 6,812 | 598,770 | 11,944 | Jul 14 04:58 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Jul 12 | Sale | 178.96 | 6,812 | 1,219,098 | 5,132 | Jul 14 04:58 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Jun 09 | Sale | 154.00 | 1,734 | 267,036 | 5,132 | Jun 11 04:13 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Jan 13 | Option Exercise | 82.45 | 9,027 | 744,290 | 11,261 | Jan 15 04:03 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Jan 13 | Sale | 169.90 | 9,027 | 1,533,698 | 2,234 | Jan 15 04:03 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Jan 12 | Option Exercise | 72.83 | 14,941 | 1,088,149 | 17,175 | Jan 13 04:05 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Jan 12 | Sale | 160.20 | 14,941 | 2,393,619 | 2,234 | Jan 13 04:05 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Jan 11 | Sale | 154.00 | 758 | 116,732 | 2,234 | Jan 13 04:05 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Jul 13 | Option Exercise | 87.16 | 35,750 | 3,116,066 | 50,242 | Jul 14 04:03 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Jul 13 | Sale | 160.67 | 47,250 | 7,591,790 | 2,992 | Jul 14 04:03 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Apr 20 | Option Exercise | 77.40 | 10,000 | 774,000 | 24,492 | Apr 22 04:07 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Apr 20 | Sale | 139.00 | 10,000 | 1,390,000 | 14,492 | Apr 22 04:07 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Feb 10 | Option Exercise | 77.40 | 10,000 | 774,000 | 22,258 | Feb 12 04:03 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Feb 10 | Sale | 129.00 | 10,000 | 1,290,000 | 12,258 | Feb 12 04:03 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Jan 29 | Option Exercise | 77.40 | 6,337 | 490,484 | 14,932 | Jan 31 04:05 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Jan 29 | Sale | 119.00 | 6,337 | 754,103 | 8,595 | Jan 31 04:05 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Jan 27 | Option Exercise | 42.22 | 34,374 | 1,451,270 | 49,632 | Jan 29 04:03 PM |
| ALNY | KEATING LAURIE | EVP, Chief Legal Officer | Jan 27 | Sale | 117.70 | 41,037 | 4,829,970 | 8,595 | Jan 29 04:03 PM |
| ALNY | KEATING LAURIE | SVP, GC & Secretary | Jun 20 | Option Exercise | 42.22 | 1,563 | 65,990 | 16,063 | Jun 22 04:20 PM |
| ALNY | KEATING LAURIE | SVP, GC & Secretary | Jun 20 | Sale | 105.04 | 1,563 | 164,178 | 14,500 | Jun 22 04:20 PM |
| ALNY | KEATING LAURIE | SVP, GC & Secretary | Mar 20 | Option Exercise | 42.22 | 1,562 | 65,948 | 16,062 | Mar 22 06:18 PM |
| ALNY | KEATING LAURIE | SVP, GC & Secretary | Mar 20 | Sale | 149.83 | 1,562 | 234,033 | 14,500 | Mar 22 06:18 PM |
| ALNY | KEATING LAURIE | SVP, GC & Secretary | Mar 12 | Option Exercise | 77.40 | 10,000 | 774,000 | 24,500 | Mar 14 07:40 PM |
| ALNY | KEATING LAURIE | SVP, GC & Secretary | Mar 13 | Option Exercise | 77.40 | 10,000 | 774,000 | 24,500 | Mar 14 07:40 PM |
| ALNY | KEATING LAURIE | SVP, GC & Secretary | Mar 13 | Sale | 150.00 | 10,000 | 1,500,000 | 14,500 | Mar 14 07:40 PM |
| ALNY | KEATING LAURIE | SVP, GC & Secretary | Mar 12 | Sale | 140.00 | 10,000 | 1,400,000 | 14,500 | Mar 14 07:40 PM |
| ALNY | KEATING LAURIE | SVP, GC & Secretary | Dec 29 | Option Exercise | 77.40 | 3,000 | 232,200 | 14,500 | Jan 03 05:13 PM |
| ALNY | KEATING LAURIE | SVP, GC & Secretary | Dec 20 | Option Exercise | 42.22 | 6,249 | 263,833 | 17,749 | Dec 21 05:00 PM |
| ALNY | KEATING LAURIE | SVP, GC & Secretary | Dec 20 | Sale | 121.20 | 6,249 | 757,398 | 11,500 | Dec 21 05:00 PM |
| ALNY | KEATING LAURIE | SVP, GC and Secretary | Dec 01 | Option Exercise | 77.40 | 30,000 | 2,322,000 | 41,500 | Dec 05 05:47 PM |
| ALNY | KEATING LAURIE | SVP, GC and Secretary | Dec 01 | Sale | 135.89 | 30,000 | 4,076,823 | 11,500 | Dec 05 05:47 PM |
| ALNY | KEATING LAURIE | SVP, GC and Secretary | May 30 | Buy | 65.35 | 11,500 | 751,502 | 11,500 | May 31 05:22 PM |
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