Opaleye Management Inc. - Insider Transactions

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Ticker	Owner	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
HROW	Opaleye Management Inc.	10% Owner	Mar 28	Buy	12.82	50,000	641,000	3,745,600	Mar 28 06:07 PM
HROW	Opaleye Management Inc.	10% Owner	Mar 20	Buy	9.65	50,600	488,290	3,695,600	Mar 22 11:52 AM
HROW	Opaleye Management Inc.	10% Owner	Nov 15	Buy	8.03	25,000	200,735	3,645,000	Nov 16 04:05 PM
HROW	Opaleye Management Inc.	10% Owner	Sep 19	Buy	14.65	14,017	205,366	3,614,017	Sep 20 06:39 PM
HROW	Opaleye Management Inc.	10% Owner	Sep 20	Buy	14.49	5,983	86,710	3,620,000	Sep 20 06:39 PM

TCON	Opaleye Management Inc.	10% Owner	Mar 09	Buy	1.38	174,508	240,821	4,324,508	Mar 13 04:05 PM
TCON	Opaleye Management Inc.	10% Owner	Dec 14	Buy	1.25	167,500	209,876	4,150,000	Dec 16 05:03 PM
HROW	Opaleye Management Inc.	10% Owner	Dec 14	Buy	10.52	431,183	4,536,045	3,600,000	Dec 14 04:05 PM
TCON	Opaleye Management Inc.	10% Owner	Dec 06	Sale	1.44	1,539	2,216	4,010,000	Dec 08 06:49 PM
TELA	Opaleye Management Inc.	10% Owner	Nov 03	Buy	7.81	20,262	158,285	1,948,000	Nov 04 04:03 PM
TCON	Opaleye Management Inc.	10% Owner	Oct 18	Buy	1.65	12,500	20,625	4,125,000	Oct 19 07:22 PM
TELA	Opaleye Management Inc.	10% Owner	Oct 11	Buy	8.00	16,000	128,000	1,929,000	Oct 11 07:29 PM
TCON	Opaleye Management Inc.	10% Owner	Sep 29	Buy	1.74	9,400	16,370	410,000	Oct 03 04:06 PM
HROW	Opaleye Management Inc.	10% Owner	Sep 28	Buy	9.77	11,085	108,354	3,185,000	Sep 30 06:15 AM
TCON	Opaleye Management Inc.	10% Owner	Sep 27	Buy	1.69	1,700	2,877	400,600	Sep 28 06:00 PM

TELA	Opaleye Management Inc.	10% Owner	Sep 23	Buy	7.99	6,804	54,393	1,914,000	Sep 26 04:05 PM
TCON	Opaleye Management Inc.	10% Owner	Sep 22	Buy	1.73	17,311	29,943	3,780,000	Sep 22 06:09 PM
TCON	Opaleye Management Inc.	10% Owner	Sep 20	Buy	1.85	10,000	18,524	385,000	Sep 20 05:37 PM
TELA	Opaleye Management Inc.	10% Owner	Sep 19	Buy	8.09	18,000	145,584	1,907,500	Sep 19 07:27 PM
TCON	Opaleye Management Inc.	10% Owner	Sep 19	Buy	1.87	5,000	9,366	375,000	Sep 19 07:00 PM
TELA	Opaleye Management Inc.	10% Owner	Sep 15	Buy	8.10	4,158	33,680	1,888,500	Sep 16 05:47 PM
TELA	Opaleye Management Inc.	10% Owner	Sep 16	Buy	8.08	2,372	19,173	1,890,500	Sep 16 05:47 PM
TELA	Opaleye Management Inc.	10% Owner	Aug 16	Buy	8.10	5,221	42,285	1,885,000	Sep 15 04:05 PM
TARA	Opaleye Management Inc.	10% Owner	Sep 14	Buy	3.98	16,600	66,068	2,570,777	Sep 15 04:05 PM
TARA	Opaleye Management Inc.	10% Owner	Sep 15	Buy	3.80	7,300	27,740	2,575,777	Sep 15 04:05 PM
TELA	Opaleye Management Inc.	10% Owner	Aug 16	Buy	8.00	315,000	2,520,000	1,880,000	Aug 16 04:05 PM
TELA	Opaleye Management Inc.	10% Owner	Aug 10	Buy	8.52	11,979	102,089	1,580,000	Aug 12 06:41 AM
TELA	Opaleye Management Inc.	10% Owner	Aug 01	Buy	7.96	4,979	39,632	1,565,500	Aug 02 09:39 PM
TCON	Opaleye Management Inc.	10% Owner	Jul 26	Buy	1.72	2,254	3,877	370,000	Jul 26 05:25 PM
TELA	Opaleye Management Inc.	10% Owner	Jul 22	Buy	8.02	5,200	41,709	1,564,000	Jul 22 05:48 PM

TELA	Opaleye Management Inc.	10% Owner	Jul 21	Buy	8.03	10,333	83,010	1,559,000	Jul 21 05:50 PM
TELA	Opaleye Management Inc.	10% Owner	Jul 20	Buy	8.08	5,100	41,192	1,549,500	Jul 20 06:55 PM
TCON	Opaleye Management Inc.	10% Owner	Jul 15	Buy	1.78	11,826	21,068	367,746	Jul 15 06:06 PM
TCON	Opaleye Management Inc.	10% Owner	Jul 14	Buy	1.81	7,187	13,024	355,920	Jul 14 06:25 PM
TELA	Opaleye Management Inc.	10% Owner	Jul 01	Buy	7.00	200	1,400	98,567	Jul 05 06:30 PM
TELA	Opaleye Management Inc.	10% Owner	Jun 29	Buy	6.99	2	14	1,542,002	Jun 30 07:20 PM
TELA	Opaleye Management Inc.	10% Owner	Jun 30	Buy	7.00	3,565	24,955	1,545,000	Jun 30 07:20 PM
TCON	Opaleye Management Inc.	10% Owner	Jun 24	Buy	1.39	11,419	15,894	348,733	Jun 27 04:05 PM
TELA	Opaleye Management Inc.	10% Owner	Jun 22	Buy	6.99	2,400	16,776	1,542,000	Jun 24 07:45 PM
TCON	Opaleye Management Inc.	10% Owner	Jun 21	Buy	1.31	841,989	1,105,279	3,776,589	Jun 23 06:54 PM
TELA	Opaleye Management Inc.	10% Owner	Jun 10	Buy	6.50	2,400	15,599	97,400	Jun 22 05:18 PM
TELA	Opaleye Management Inc.	10% Owner	Jun 22	Buy	6.50	50,000	324,975	1,540,000	Jun 22 05:18 PM
TELA	Opaleye Management Inc.	10% Owner	Jun 10	Buy	5.60	27,500	154,066	1,490,000	Jun 10 06:16 PM
TCON	Opaleye Management Inc.	10% Owner	May 10	Buy	1.76	9,700	17,032	2,934,600	May 10 07:58 PM
TCON	Opaleye Management Inc.	10% Owner	Apr 22	Buy	1.98	7,100	14,058	2,926,100	Apr 29 06:27 PM
TCON	Opaleye Management Inc.	10% Owner	Apr 22	Buy	2.24	42,000	93,941	2,910,000	Apr 25 05:55 PM
TCON	Opaleye Management Inc.	10% Owner	Apr 25	Buy	2.18	10,777	23,497	2,920,000	Apr 25 05:55 PM
TCON	Opaleye Management Inc.	10% Owner	Apr 13	Buy	2.50	7,345	18,361	2,862,296	Apr 14 06:13 PM
TCON	Opaleye Management Inc.	10% Owner	Apr 14	Buy	2.50	12,696	31,730	2,872,296	Apr 14 06:13 PM
HROW	Opaleye Management Inc.	10% Owner	Apr 12	Buy	6.75	28,557	192,717	3,165,000	Apr 13 06:33 PM
HROW	Opaleye Management Inc.	10% Owner	Apr 13	Buy	6.76	12,832	86,785	3,175,000	Apr 13 06:33 PM
TCON	Opaleye Management Inc.	10% Owner	Apr 11	Buy	2.42	9,100	22,019	2,844,198	Apr 12 07:38 PM
TCON	Opaleye Management Inc.	10% Owner	Apr 12	Buy	2.48	18,098	44,827	2,857,296	Apr 12 07:38 PM
TARA	Opaleye Management Inc.	10% Owner	Apr 07	Buy	4.74	2,345	11,123	2,551,345	Apr 08 06:45 PM
TARA	Opaleye Management Inc.	10% Owner	Apr 08	Buy	4.80	7,791	37,364	2,556,667	Apr 08 06:45 PM
TCON	Opaleye Management Inc.	10% Owner	Mar 16	Buy	2.20	2,235	4,917	2,837,735	Mar 17 04:05 PM
TARA	Opaleye Management Inc.	10% Owner	Jan 28	Buy	4.96	24,031	119,271	2,550,000	Jan 31 04:05 PM
TCON	Opaleye Management Inc.	10% Owner	Jan 28	Buy	2.20	500	1,100	2,820,500	Jan 31 04:05 PM
HROW	Opaleye Management Inc.	10% Owner	Jan 28	Buy	6.89	6,343	43,686	3,140,000	Jan 31 04:05 PM
TCON	Opaleye Management Inc.	10% Owner	Jan 21	Buy	2.19	35,000	76,811	2,820,000	Jan 24 06:18 PM
TCON	Opaleye Management Inc.	10% Owner	Jan 24	Buy	2.05	17,363	35,603	2,835,000	Jan 24 06:18 PM
TCON	Opaleye Management Inc.	10% Owner	Jan 19	Buy	2.24	23,688	53,080	2,770,000	Jan 21 04:00 PM
TCON	Opaleye Management Inc.	10% Owner	Jan 20	Buy	2.25	21,312	47,952	2,790,000	Jan 21 04:00 PM
TARA	Opaleye Management Inc.	10% Owner	Dec 28	Buy	6.36	7,091	45,090	2,530,000	Dec 29 07:36 PM
TARA	Opaleye Management Inc.	10% Owner	Dec 29	Buy	6.98	4,500	31,408	120,000	Dec 29 07:36 PM
TCON	Opaleye Management Inc.	10% Owner	Dec 29	Buy	2.51	52,325	131,362	2,750,000	Dec 29 07:14 PM
TCON	Opaleye Management Inc.	10% Owner	Dec 27	Buy	2.92	87,325	255,103	2,592,371	Dec 29 04:05 PM
TCON	Opaleye Management Inc.	10% Owner	Dec 28	Buy	2.63	20,125	52,950	2,717,675	Dec 29 04:05 PM
TARA	Opaleye Management Inc.	10% Owner	Dec 23	Buy	6.60	1,300	8,580	2,496,709	Dec 27 06:52 PM
TARA	Opaleye Management Inc.	10% Owner	Dec 27	Buy	6.53	36,700	239,713	2,528,409	Dec 27 06:52 PM
TARA	Opaleye Management Inc.	10% Owner	Dec 20	Buy	6.49	703	4,562	2,496,209	Dec 22 04:05 PM
TARA	Opaleye Management Inc.	10% Owner	Dec 16	Buy	6.41	7,563	48,485	2,493,206	Dec 20 04:00 PM
TARA	Opaleye Management Inc.	10% Owner	Dec 17	Buy	6.60	2,790	18,414	2,495,506	Dec 20 04:00 PM
TCON	Opaleye Management Inc.	10% Owner	Dec 15	Buy	2.43	21,964	53,287	2,517,371	Dec 16 04:01 PM
TCON	Opaleye Management Inc.	10% Owner	Dec 13	Buy	2.64	15,204	40,154	2,462,371	Dec 15 04:05 PM
TCON	Opaleye Management Inc.	10% Owner	Dec 14	Buy	2.53	42,000	106,344	2,497,371	Dec 15 04:05 PM
TCON	Opaleye Management Inc.	10% Owner	Dec 03	Buy	2.30	89,274	204,911	2,428,371	Dec 07 04:05 PM
TCON	Opaleye Management Inc.	10% Owner	Dec 06	Buy	2.26	22,733	51,474	2,448,371	Dec 07 04:05 PM
TCON	Opaleye Management Inc.	10% Owner	Dec 01	Buy	2.40	50,000	120,160	2,338,371	Dec 03 05:14 PM
TCON	Opaleye Management Inc.	10% Owner	Dec 02	Buy	2.35	10,500	24,660	2,348,371	Dec 03 05:14 PM
TARA	Opaleye Management Inc.	10% Owner	Nov 17	Buy	6.98	9,118	63,644	2,472,500	Nov 19 04:10 PM
TARA	Opaleye Management Inc.	10% Owner	Nov 18	Buy	6.98	15,206	106,130	2,486,706	Nov 19 04:10 PM
ETON	Opaleye Management Inc.	10% Owner	Nov 17	Sale	4.67	25,000	116,712	2,375,000	Nov 19 04:09 PM
ETON	Opaleye Management Inc.	10% Owner	Nov 15	Sale	4.80	3,000	14,405	85,938	Nov 17 04:33 PM
ETON	Opaleye Management Inc.	10% Owner	Nov 16	Sale	4.86	12,438	60,472	85,000	Nov 17 04:33 PM
ETON	Opaleye Management Inc.	10% Owner	Nov 05	Sale	6.30	167,701	1,056,701	89,099	Nov 09 04:46 PM
ETON	Opaleye Management Inc.	10% Owner	Nov 08	Sale	6.10	52,661	321,285	86,438	Nov 09 04:46 PM
TARA	Opaleye Management Inc.	10% Owner	Nov 04	Buy	6.50	6,557	42,620	2,464,472	Nov 08 02:30 PM
ETON	Opaleye Management Inc.	10% Owner	Nov 03	Sale	6.53	116,500	760,850	101,500	Nov 05 04:13 PM
ETON	Opaleye Management Inc.	10% Owner	Nov 04	Sale	6.44	85,700	551,651	97,500	Nov 05 04:13 PM
ETON	Opaleye Management Inc.	10% Owner	Oct 08	Sale	5.00	43,692	218,469	114,408	Oct 13 07:57 AM
ETON	Opaleye Management Inc.	10% Owner	Oct 11	Sale	5.01	34,101	170,716	112,807	Oct 13 07:57 AM
ETON	Opaleye Management Inc.	10% Owner	Oct 12	Sale	5.06	87,307	441,485	117,100	Oct 13 07:57 AM
HROW	Opaleye Management Inc.	10% Owner	Aug 19	Buy	8.45	52,500	443,362	3,135,000	Aug 23 05:59 PM
HROW	Opaleye Management Inc.	10% Owner	Aug 17	Buy	8.57	26,000	222,719	3,040,000	Aug 19 07:10 PM
HROW	Opaleye Management Inc.	10% Owner	Aug 18	Buy	8.64	46,500	401,979	3,085,000	Aug 19 07:10 PM
ETON	Opaleye Management Inc.	10% Owner	Aug 04	Sale	5.75	104,000	598,146	137,600	Aug 06 09:53 PM
ETON	Opaleye Management Inc.	10% Owner	Aug 05	Sale	5.85	155,500	910,173	132,100	Aug 06 09:53 PM
ETON	Opaleye Management Inc.	10% Owner	Aug 06	Sale	5.84	345,000	2,014,869	117,100	Aug 06 09:53 PM
HROW	Opaleye Management Inc.	10% Owner	Jul 19	Buy	6.97	5,869	40,897	3,005,700	Jul 22 09:19 AM
HROW	Opaleye Management Inc.	10% Owner	Jul 20	Buy	7.20	4,925	35,460	3,010,500	Jul 22 09:19 AM
HROW	Opaleye Management Inc.	10% Owner	Jul 21	Buy	7.60	9,206	69,933	3,015,000	Jul 22 09:19 AM
HROW	Opaleye Management Inc.	10% Owner	Jun 17	Buy	8.32	11,262	93,701	2,940,200	Jun 22 11:44 AM
HROW	Opaleye Management Inc.	10% Owner	Jun 18	Buy	8.35	63,322	528,688	3,000,000	Jun 22 11:44 AM
ETON	Opaleye Management Inc.	10% Owner	Jun 15	Sale	8.07	105,000	847,350	141,600	Jun 17 04:39 PM
ETON	Opaleye Management Inc.	10% Owner	May 25	Sale	8.53	48,000	409,440	153,000	May 27 07:34 PM
ETON	Opaleye Management Inc.	10% Owner	May 26	Sale	8.57	68,300	585,331	150,200	May 27 07:34 PM
ETON	Opaleye Management Inc.	10% Owner	May 27	Sale	8.49	126,000	1,069,740	145,600	May 27 07:34 PM
TCON	Opaleye Management Inc.	10% Owner	Dec 22	Buy	8.06	496,277	3,999,993	2,293,371	Dec 28 09:53 AM
HROW	Opaleye Management Inc.	10% Owner	Dec 18	Buy	5.31	36,400	193,379	2,862,100	Dec 22 06:09 PM
HROW	Opaleye Management Inc.	10% Owner	Dec 21	Buy	5.24	53,459	280,093	2,913,500	Dec 22 06:09 PM
HROW	Opaleye Management Inc.	10% Owner	Dec 22	Buy	5.19	16,557	86,010	2,929,400	Dec 22 06:09 PM
TCON	Opaleye Management Inc.	10% Owner	Oct 21	Buy	4.40	8,656	38,060	1,797,094	Oct 23 09:30 PM
ETON	Opaleye Management Inc.	10% Owner	Oct 16	Buy	7.00	400,000	2,800,000	3,885,000	Oct 16 09:30 PM
TARA	Opaleye Management Inc.	10% Owner	Sep 30	Buy	16.00	50,000	800,000	2,458,472	Oct 02 06:05 AM
TCON	Opaleye Management Inc.	10% Owner	Sep 23	Buy	4.83	57,200	276,448	1,764,438	Sep 25 09:30 PM
TCON	Opaleye Management Inc.	10% Owner	Sep 24	Buy	4.44	21,534	95,648	1,785,438	Sep 25 09:30 PM
TARA	Opaleye Management Inc.	10% Owner	Sep 24	Buy	16.87	300,000	5,061,000	2,408,472	Sep 25 05:15 PM
TCON	Opaleye Management Inc.	10% Owner	Sep 04	Buy	2.88	9,058	26,130	1,664,438	Sep 09 06:15 PM
TCON	Opaleye Management Inc.	10% Owner	Sep 09	Buy	3.47	47,500	164,773	1,709,438	Sep 09 06:15 PM
TCON	Opaleye Management Inc.	10% Owner	Sep 01	Buy	2.04	40,000	81,768	1,540,946	Sep 03 05:15 PM
TCON	Opaleye Management Inc.	10% Owner	Sep 02	Buy	2.35	119,800	282,057	1,655,946	Sep 03 05:15 PM
TCON	Opaleye Management Inc.	10% Owner	Aug 27	Buy	1.71	183,354	312,949	1,206,196	Aug 31 09:36 PM
TCON	Opaleye Management Inc.	10% Owner	Aug 28	Buy	1.78	60,000	106,974	210,000	Aug 31 09:36 PM
TCON	Opaleye Management Inc.	10% Owner	Aug 31	Buy	1.76	302,150	530,455	1,502,346	Aug 31 09:36 PM
HROW	Opaleye Management Inc.	10% Owner	Jul 10	Buy	4.98	45,000	223,965	2,761,300	Jul 14 09:45 PM
HROW	Opaleye Management Inc.	10% Owner	Jul 11	Buy	4.96	46,800	231,922	2,808,100	Jul 14 09:45 PM
HROW	Opaleye Management Inc.	10% Owner	Jul 12	Buy	4.99	20,900	104,246	2,827,100	Jul 14 09:45 PM
HROW	Opaleye Management Inc.	10% Owner	Jul 07	Buy	5.18	41,300	213,996	2,626,300	Jul 09 09:30 PM
HROW	Opaleye Management Inc.	10% Owner	Jul 08	Buy	4.99	65,000	324,630	2,691,300	Jul 09 09:30 PM
HROW	Opaleye Management Inc.	10% Owner	Jul 09	Buy	4.84	30,000	145,078	2,716,300	Jul 09 09:30 PM
HROW	Opaleye Management Inc.	10% Owner	Jun 19	Buy	5.58	35,000	195,402	2,585,000	Jun 23 09:45 PM
HROW	Opaleye Management Inc.	10% Owner	Jun 02	Buy	5.69	19,400	110,339	2,519,400	Jun 04 06:06 PM
HROW	Opaleye Management Inc.	10% Owner	Jun 03	Buy	5.74	20,600	118,308	2,540,000	Jun 04 06:06 PM
HROW	Opaleye Management Inc.	10% Owner	Jun 04	Buy	5.79	10,000	57,861	2,550,000	Jun 04 06:06 PM
HROW	Opaleye Management Inc.	10% Owner	May 20	Buy	4.49	1,500	6,739	2,480,800	May 22 07:22 PM
HROW	Opaleye Management Inc.	10% Owner	May 21	Buy	4.66	10,596	49,338	2,491,196	May 22 07:22 PM
HROW	Opaleye Management Inc.	10% Owner	May 22	Buy	5.04	13,804	69,589	2,500,000	May 22 07:22 PM
OCUL	Opaleye Management Inc.	10% Owner	Jan 02	Buy	3.90	15,000	58,508	4,918,500	Jan 03 07:45 PM
OCUL	Opaleye Management Inc.	10% Owner	Dec 30	Buy	3.97	20,000	79,410	4,903,500	Jan 02 05:15 PM

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Opaleye Management Inc. - Insider Transactions

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