EcoR1 Capital, LLC - Insider Transactions

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Ticker	Owner	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
ZYME	EcoR1 Capital, LLC	10% Owner	Jun 16	Buy	8.12	3,350,000	27,202,000	13,437,473	Jun 21 04:04 PM
ZYME	EcoR1 Capital, LLC	10% Owner	Mar 28	Buy	8.00	200,000	1,600,000	10,087,473	Mar 30 05:47 PM
ZYME	EcoR1 Capital, LLC	10% Owner	Jan 19	Buy	9.49	144,100	1,367,639	9,724,073	Jan 23 06:00 PM
ZYME	EcoR1 Capital, LLC	10% Owner	Jan 20	Buy	9.88	163,400	1,615,095	9,887,473	Jan 23 06:00 PM
ZYME	EcoR1 Capital, LLC	10% Owner	Jan 13	Buy	9.81	342,100	3,354,633	8,936,973	Jan 18 06:27 PM

ZYME	EcoR1 Capital, LLC	10% Owner	Jan 17	Buy	9.80	440,000	4,313,848	9,376,973	Jan 18 06:27 PM
ZYME	EcoR1 Capital, LLC	10% Owner	Jan 18	Buy	10.00	203,000	2,029,046	9,579,973	Jan 18 06:27 PM
ZYME	EcoR1 Capital, LLC	10% Owner	Jan 10	Buy	7.65	920,000	7,037,172	8,488,573	Jan 12 04:47 PM
ZYME	EcoR1 Capital, LLC	10% Owner	Jan 11	Buy	7.87	106,300	836,911	8,594,873	Jan 12 04:47 PM
VYGR	EcoR1 Capital, LLC	10% Owner	Jan 09	Sale	7.67	456,000	3,498,295	4,297,907	Jan 11 06:26 PM
VYGR	EcoR1 Capital, LLC	10% Owner	Jan 10	Sale	8.05	336,400	2,709,433	3,961,507	Jan 11 06:26 PM
VYGR	EcoR1 Capital, LLC	10% Owner	Jan 11	Sale	8.50	110,000	934,615	3,851,507	Jan 11 06:26 PM
VYGR	EcoR1 Capital, LLC	10% Owner	Jun 21	Buy	5.28	101,400	535,504	4,377,907	Jun 23 05:21 PM
VYGR	EcoR1 Capital, LLC	10% Owner	Jun 23	Buy	5.66	376,000	2,126,543	4,753,907	Jun 23 05:21 PM
ANAB	EcoR1 Capital, LLC	10% Owner	May 05	Buy	21.63	668,237	14,453,966	7,521,024	May 09 06:04 AM

ANAB	EcoR1 Capital, LLC	10% Owner	May 05	Sale	21.63	668,237	14,453,966	7,521,024	May 09 06:04 AM
PRTA	EcoR1 Capital, LLC	10% Owner	May 05	Buy	29.02	1,062,736	30,840,599	11,584,280	May 09 06:01 AM
PRTA	EcoR1 Capital, LLC	10% Owner	May 05	Sale	29.02	1,062,736	30,840,599	11,584,280	May 09 06:01 AM
PRTA	EcoR1 Capital, LLC	10% Owner	Jan 12	Buy	37.50	300,000	11,250,300	11,584,280	Jan 12 06:12 PM
CRVS	EcoR1 Capital, LLC	10% Owner	Sep 30	Sale	5.04	3,000,000	15,131,100	2,081,077	Oct 01 07:39 PM
CRVS	EcoR1 Capital, LLC	10% Owner	Oct 01	Sale	4.96	2,000,000	9,928,800	81,077	Oct 01 07:39 PM
ANAB	EcoR1 Capital, LLC	Director	Apr 30	Buy	23.16	35,700	826,816	7,334,624	May 04 04:51 PM
ANAB	EcoR1 Capital, LLC	Director	May 03	Buy	23.31	20,800	484,873	7,355,424	May 04 04:51 PM
ANAB	EcoR1 Capital, LLC	Director	May 04	Buy	23.25	165,000	3,835,755	7,520,424	May 04 04:51 PM
ANAB	EcoR1 Capital, LLC	Director	Apr 23	Buy	23.54	99,600	2,344,285	7,251,224	Apr 27 06:23 PM
ANAB	EcoR1 Capital, LLC	Director	Apr 26	Buy	23.80	13,900	330,859	7,265,124	Apr 27 06:23 PM
ANAB	EcoR1 Capital, LLC	Director	Apr 27	Buy	23.82	33,800	805,089	7,298,924	Apr 27 06:23 PM
PRTA	EcoR1 Capital, LLC	10% Owner	Mar 24	Buy	20.75	875,000	18,156,250	11,034,280	Mar 25 11:14 AM
ANAB	EcoR1 Capital, LLC	10% Owner	Mar 08	Buy	18.97	2,777,800	52,694,310	6,620,624	Mar 10 05:53 PM
ANAB	EcoR1 Capital, LLC	10% Owner	Mar 09	Buy	18.70	531,000	9,928,426	7,151,624	Mar 10 05:53 PM

PRTA	EcoR1 Capital, LLC	10% Owner	Feb 23	Buy	21.05	44,400	934,518	10,148,480	Feb 25 06:00 PM
PRTA	EcoR1 Capital, LLC	10% Owner	Feb 24	Buy	22.02	10,800	237,867	10,159,280	Feb 25 06:00 PM
ANAB	EcoR1 Capital, LLC	10% Owner	Feb 23	Buy	25.48	29,500	751,657	3,842,824	Feb 25 05:58 PM
PRTA	EcoR1 Capital, LLC	10% Owner	Feb 18	Buy	3.68	44,100	162,103	10,104,080	Feb 22 04:24 PM
PRTA	EcoR1 Capital, LLC	10% Owner	Feb 12	Buy	20.16	345,300	6,959,761	9,771,940	Feb 17 07:14 PM
PRTA	EcoR1 Capital, LLC	10% Owner	Feb 16	Buy	22.78	89,200	2,031,967	9,861,140	Feb 17 07:14 PM
PRTA	EcoR1 Capital, LLC	10% Owner	Feb 17	Buy	23.46	198,840	4,665,542	10,059,980	Feb 17 07:14 PM

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EcoR1 Capital, LLC - Insider Transactions

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