ADAGE CAPITAL PARTNERS GP, L.L.C. - Insider Transactions

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Ticker	Owner	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
RPRX	ADAGE CAPITAL PARTNERS GP, L.L	10% Owner	Dec 17 '20	Sale	43.92	7,200,000	316,224,000	38,815,330	Dec 18 02:36 PM
RPRX	ADAGE CAPITAL PARTNERS GP, L.L	10% Owner	Dec 18 '20	Sale	44.02	101,050	4,448,221	38,714,280	Dec 18 02:36 PM
RPRX	ADAGE CAPITAL PARTNERS GP, L.L	10% Owner	Jun 18 '20	Buy	28.00	3,000,000	84,000,000	46,015,330	Jun 22 05:31 PM
PBYI	ADAGE CAPITAL PARTNERS GP, L.L	10% Owner	Jun 08 '17	Sale	80.95	100,000	8,094,610	3,843,840	Jun 12 06:45 PM
PBYI	ADAGE CAPITAL PARTNERS GP, L.L	10% Owner	Jun 09 '17	Sale	80.77	58,316	4,710,430	3,785,524	Jun 12 06:45 PM

PBYI	ADAGE CAPITAL PARTNERS GP, L.L	10% Owner	Jun 12 '17	Sale	79.31	88,944	7,053,870	3,696,580	Jun 12 06:45 PM
PBYI	ADAGE CAPITAL PARTNERS GP, L.L	10% Owner	Jun 01 '17	Sale	82.45	169,525	13,976,657	4,281,443	Jun 05 05:58 PM
PBYI	ADAGE CAPITAL PARTNERS GP, L.L	10% Owner	Jun 02 '17	Sale	83.06	30,475	2,531,287	4,250,968	Jun 05 05:58 PM
PBYI	ADAGE CAPITAL PARTNERS GP, L.L	10% Owner	Jun 05 '17	Sale	91.29	307,128	28,037,032	3,943,840	Jun 05 05:58 PM
PBYI	ADAGE CAPITAL PARTNERS GP, L.L	10% Owner	May 24 '17	Sale	72.57	535,700	38,876,445	5,150,968	May 26 04:40 PM
PBYI	ADAGE CAPITAL PARTNERS GP, L.L	10% Owner	May 25 '17	Sale	77.87	400,000	31,146,560	4,750,968	May 26 04:40 PM
PBYI	ADAGE CAPITAL PARTNERS GP, L.L	10% Owner	May 26 '17	Sale	77.07	300,000	23,121,263	4,450,968	May 26 04:40 PM

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